An informatic workflow for the enhanced annotation of excretory/secretory proteins of Haemonchus contortus

Abstract

Major advances in genomic and associated technologies have demanded reliable bioinformatic tools and workflows for the annotation of genes and their products via comparative analyses using well-curated reference data sets, accessible in public repositories. However, the accurate in silico annotation of molecules (proteins) encoded in organisms (e.g., multicellular parasites) which are evolutionarily distant from those for which these extensive reference data sets are available, including invertebrate model organisms (e.g., Caenorhabditis elegans – free-living nematode, and Drosophila melanogaster – the vinegar fly) and vertebrate species (e.g., Homo sapiens and Mus musculus), remains a major..